This review discusses recent advancements in the merging of nanotechnology with 3D printed tissue engineering scaffolds, with a focus on applications of nanoscale components, nanoscale texture, and innovative printing techniques and the effects observed in vitro and in vivo.ģD printing Nanoscale texture Nanotechnology Scaffold Tissue engineering.Ĭopyright © 2021 Elsevier B.V. Nanotechnological components, nanoscale textures, and microscale/nanoscale printing can all be incorporated into the manufacture of 3D printed scaffolds. Such scaffolds can be functionalized with techniques developed by nanotechnology research to further enhance their ability to stimulate regeneration and interact with cells. Tissue engineered meniscus provides a novel approach for the treatment of severe meniscus injury. Three-dimensional (3D) printing is a promising technique for the fabrication of structurally intricate and compositionally complex tissue engineering scaffolds. Unsurprisingly, their functions should mimic the ECM of the target. Introduction: Stem cells and scaffolds are an important foundation and starting point for tissue engineering. Early work in tissue engineering mostly used materials as inert scaffolding structures, but research has shown that constructing scaffolds from biologically active materials can help with regeneration by enabling cell-scaffold interactions or release of factors that aid in regeneration. Scaffolds in engineered tissues are to mimic the ECM in native tissues, at least partially. Due to the prevalence of cardiovascular diseases, there is a large need for small diameter vascular grafts that cannot be fulfilled using autologous vessels. Scaffold-based tissue engineering requires a resorbable scaffold that can restore function and guide regeneration. Tissue engineering is an interdisciplinary field that aims to combine life sciences and engineering to create therapies that regenerate functional tissue. Electrospun nanofiber scaffold for vascular tissue engineering.
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